5TI7
CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH INHIBITOR 17528462
Summary for 5TI7
Entry DOI | 10.2210/pdb5ti7/pdb |
Related | 5TI2 5TI3 5TI4 5TI5 5TI6 |
Descriptor | Bromodomain-containing protein 4, 5-bromo-2-methoxy-N-(3-(2-oxopyrrolidin-1-yl)phenyl)benzenesulfonamide, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | bromodomain, cap, hunk1, mcap, protein binding-inhibitor complex, mitotic chromosome associated protein, cell cycle, inhibitor, transcription-inhibitor complex, transcription/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 15772.95 |
Authors | Zhu, J.-Y.,Ember, S.W.J.,Schonbrunn, E. (deposition date: 2016-10-01, release date: 2017-08-09, Last modification date: 2024-02-28) |
Primary citation | Allen, B.K.,Mehta, S.,Ember, S.W.J.,Zhu, J.Y.,Schonbrunn, E.,Ayad, N.G.,Schurer, S.C. Identification of a Novel Class of BRD4 Inhibitors by Computational Screening and Binding Simulations. ACS Omega, 2:4760-4771, 2017 Cited by PubMed: 28884163DOI: 10.1021/acsomega.7b00553 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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