5TFA

Nucleotide-binding domain 1 of the human cystic fibrosis transmembrane conductance regulator (CFTR) with dUTP

5TFA の概要

• エントリーDOI: 10.2210/pdb5tfa/pdb
• 関連するPDBエントリー: 5TF7 5TF8 5TFB 5TFC 5TFD 5TFE 5TFF 5TFG 5TFH 5TFI 5TFJ 5TGK
• 分子名称: Cystic fibrosis transmembrane conductance regulator, DEOXYURIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: hnbd1, cftr, abc transport, atp, hydrolase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Apical cell membrane ; Multi-pass membrane protein {ECO:0000269|Ref: P13569
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 26017.85

構造登録者

Wang, C.,Aleksandrov, A.A.,Yang, Z.,Forouhar, F.,Proctor, E.,Kota, P.,An, J.,Kaplan, A.,Khazanov, N.,Boel, G.,Stockwell, B.R.,Senderowitz, H.,Dokholyan, N.V.,Riordan, J.R.,Brouillette, C.G.,Hunt, J.F. (登録日: 2016-09-24, 公開日: 2018-05-09, 最終更新日: 2023-10-04)

• 主引用文献: Wang, C.,Aleksandrov, A.A.,Yang, Z.,Forouhar, F.,Proctor, E.,Kota, P.,An, J.,Kaplan, A.,Khazanov, N.,Boel, G.,Stockwell, B.R.,Senderowitz, H.,Dokholyan, N.V.,Riordan, J.R.,Brouillette, C.G.,Hunt, J.F.; Thermodynamic correction of F508del-CFTR by ligand binding to a remote site in the mutated domain; To Be Published,

実験手法

X-RAY DIFFRACTION (1.87 Å)