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5TF9

Crystal structure of WNK1 in complex with Mn2+AMPPNP and WNK476

Summary for 5TF9
Entry DOI10.2210/pdb5tf9/pdb
DescriptorSerine/threonine-protein kinase WNK1, {2-[(4-chlorophenyl)methoxy]phenyl}{5-[2-(methylamino)-1,3-thiazol-4-yl]-2,3-dihydro-1H-indol-1-yl}methanone, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (6 entities in total)
Functional Keywordsserine-threonine-protein kinase, inhibitor, ternary, complex, allosteric, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm : Q9H4A3
Total number of polymer chains2
Total formula weight65902.15
Authors
Xie, X.,Gunawan, J. (deposition date: 2016-09-24, release date: 2016-10-19, Last modification date: 2023-10-04)
Primary citationYamada, K.,Zhang, J.H.,Xie, X.,Reinhardt, J.,Xie, A.Q.,LaSala, D.,Kohls, D.,Yowe, D.,Burdick, D.,Yoshisue, H.,Wakai, H.,Schmidt, I.,Gunawan, J.,Yasoshima, K.,Yue, Q.K.,Kato, M.,Mogi, M.,Idamakanti, N.,Kreder, N.,Drueckes, P.,Pandey, P.,Kawanami, T.,Huang, W.,Yagi, Y.I.,Deng, Z.,Park, H.M.
Discovery and Characterization of Allosteric WNK Kinase Inhibitors.
ACS Chem. Biol., 11:3338-3346, 2016
Cited by
PubMed: 27712055
DOI: 10.1021/acschembio.6b00511
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

217705

數據於2024-03-27公開中

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