5TF9

Crystal structure of WNK1 in complex with Mn2+AMPPNP and WNK476

5TF9 の概要

• エントリーDOI: 10.2210/pdb5tf9/pdb
• 分子名称: Serine/threonine-protein kinase WNK1, {2-[(4-chlorophenyl)methoxy]phenyl}{5-[2-(methylamino)-1,3-thiazol-4-yl]-2,3-dihydro-1H-indol-1-yl}methanone, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (6 entities in total)
• 機能のキーワード: serine-threonine-protein kinase, inhibitor, ternary, complex, allosteric, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm : Q9H4A3
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 65902.15

構造登録者

Xie, X.,Gunawan, J. (登録日: 2016-09-24, 公開日: 2016-10-19, 最終更新日: 2023-10-04)

• 主引用文献: Yamada, K.,Zhang, J.H.,Xie, X.,Reinhardt, J.,Xie, A.Q.,LaSala, D.,Kohls, D.,Yowe, D.,Burdick, D.,Yoshisue, H.,Wakai, H.,Schmidt, I.,Gunawan, J.,Yasoshima, K.,Yue, Q.K.,Kato, M.,Mogi, M.,Idamakanti, N.,Kreder, N.,Drueckes, P.,Pandey, P.,Kawanami, T.,Huang, W.,Yagi, Y.I.,Deng, Z.,Park, H.M.; Discovery and Characterization of Allosteric WNK Kinase Inhibitors.; ACS Chem. Biol., 11:3338-3346, 2016; PubMed: 27712055; DOI: 10.1021/acschembio.6b00511

実験手法

X-RAY DIFFRACTION (2.5 Å)