5TE6

Crystal Structure of Broadly Neutralizing VRC01-class Antibody N6 in Complex with HIV-1 Clade AE Strain 93TH057 gp120 Core

Summary for 5TE6

• Entry DOI: 10.2210/pdb5te6/pdb
• Related: 5TE4 5TE7
• Descriptor: clade A/E 93TH057 HIV-1 gp120 core, Heavy chain of N6, Light chain of N6, ... (6 entities in total)
• Functional Keywords: hiv-1, vrc01-class antibody, n6, cd4-binding site, gp120, immune system
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 3
• Total formula weight: 89236.02

Authors

Zhou, T.,Kwong, P.D. (deposition date: 2016-09-20, release date: 2016-11-16, Last modification date: 2020-07-29)

• Primary citation: Huang, J.,Kang, B.H.,Ishida, E.,Zhou, T.,Griesman, T.,Sheng, Z.,Wu, F.,Doria-Rose, N.A.,Zhang, B.,McKee, K.,O'Dell, S.,Chuang, G.Y.,Druz, A.,Georgiev, I.S.,Schramm, C.A.,Zheng, A.,Joyce, M.G.,Asokan, M.,Ransier, A.,Darko, S.,Migueles, S.A.,Bailer, R.T.,Louder, M.K.,Alam, S.M.,Parks, R.,Kelsoe, G.,Von Holle, T.,Haynes, B.F.,Douek, D.C.,Hirsch, V.,Seaman, M.S.,Shapiro, L.,Mascola, J.R.,Kwong, P.D.,Connors, M.; Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth.; Immunity, 45:1108-1121, 2016; PubMed: 27851912; DOI: 10.1016/j.immuni.2016.10.027

Experimental method

X-RAY DIFFRACTION (2.4 Å)