5TBO

Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with Inhibitor DSM421

5TBO の概要

• エントリーDOI: 10.2210/pdb5tbo/pdb
• 分子名称: Dihydroorotate dehydrogenase (quinone), mitochondrial, 2-(1,1-difluoroethyl)-5-methyl-N-[6-(trifluoromethyl)pyridin-3-yl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine, FLAVIN MONONUCLEOTIDE, ... (7 entities in total)
• 機能のキーワード: oxidoreductase, alpha/beta barrel, fmn, mitochondrial membrane, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Plasmodium falciparum (isolate 3D7)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 46770.21

構造登録者

Deng, X.,Phillips, M. (登録日: 2016-09-12, 公開日: 2016-09-28, 最終更新日: 2023-10-04)

• 主引用文献: Phillips, M.A.,White, K.L.,Kokkonda, S.,Deng, X.,White, J.,El Mazouni, F.,Marsh, K.,Tomchick, D.R.,Manjalanagara, K.,Rudra, K.R.,Wirjanata, G.,Noviyanti, R.,Price, R.N.,Marfurt, J.,Shackleford, D.M.,Chiu, F.C.,Campbell, M.,Jimenez-Diaz, M.B.,Bazaga, S.F.,Angulo-Barturen, I.,Martinez, M.S.,Lafuente-Monasterio, M.,Kaminsky, W.,Silue, K.,Zeeman, A.M.,Kocken, C.,Leroy, D.,Blasco, B.,Rossignol, E.,Rueckle, T.,Matthews, D.,Burrows, J.N.,Waterson, D.,Palmer, M.J.,Rathod, P.K.,Charman, S.A.; A Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Improved Drug-like Properties for Treatment and Prevention of Malaria.; ACS Infect Dis, 2:945-957, 2016; PubMed: 27641613; DOI: 10.1021/acsinfecdis.6b00144

実験手法

X-RAY DIFFRACTION (2.151 Å)