5TBJ

Crystal structure of mouse CARM1 in complex with inhibitor LH1452

5TBJ の概要

• エントリーDOI: 10.2210/pdb5tbj/pdb
• 分子名称: Histone-arginine methyltransferase CARM1, 2-[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]ethyl-[[4-azanyl-1-(methoxymethyl)-2-oxidanylidene-pyrimidin-5-yl]methyl]azanium, DI(HYDROXYETHYL)ETHER, ... (7 entities in total)
• 機能のキーワード: protein arginine methyltransferase, catalytic domain, chromatin regulator, mrna processing, mrna splicing, nucleus, s-adenosyl-l-methionine, transcription, transcription regulation, transferase
• 由来する生物種: Mus musculus (Mouse)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 166659.33

構造登録者

Cura, V.,Marechal, N.,Troffer-Charlier, N.,Halby, L.,Arimondo, P.,Bonnefond, L.,Cavarelli, J. (登録日: 2016-09-12, 公開日: 2017-09-20, 最終更新日: 2024-01-17)

• 主引用文献: Halby, L.,Marechal, N.,Pechalrieu, D.,Cura, V.,Franchini, D.M.,Faux, C.,Alby, F.,Troffer-Charlier, N.,Kudithipudi, S.,Jeltsch, A.,Aouadi, W.,Decroly, E.,Guillemot, J.C.,Page, P.,Ferroud, C.,Bonnefond, L.,Guianvarc'h, D.,Cavarelli, J.,Arimondo, P.B.; Hijacking DNA methyltransferase transition state analogues to produce chemical scaffolds for PRMT inhibitors.; Philos.Trans.R.Soc.Lond.B Biol.Sci., 373:-, 2018; PubMed: 29685976; DOI: 10.1098/rstb.2017.0072

実験手法

X-RAY DIFFRACTION (2.32 Å)