5T5T

AMPK bound to allosteric activator

Summary for 5T5T

• Entry DOI: 10.2210/pdb5t5t/pdb
• Descriptor: 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... (9 entities in total)
• Functional Keywords: ampk, kinase, allostery, activator, transferase
• Biological source: Rattus norvegicus (Rat); More
• Cellular location: Cytoplasm : P54645
• Total number of polymer chains: 3
• Total formula weight: 120500.96

Authors

Calabrese, M.F.,Kurumbail, R.G. (deposition date: 2016-08-31, release date: 2017-03-29, Last modification date: 2023-10-04)

• Primary citation: Salatto, C.T.,Miller, R.A.,Cameron, K.O.,Cokorinos, E.,Reyes, A.,Ward, J.,Calabrese, M.F.,Kurumbail, R.G.,Rajamohan, F.,Kalgutkar, A.S.,Tess, D.A.,Shavnya, A.,Genung, N.E.,Edmonds, D.J.,Jatkar, A.,Maciejewski, B.S.,Amaro, M.,Gandhok, H.,Monetti, M.,Cialdea, K.,Bollinger, E.,Kreeger, J.M.,Coskran, T.M.,Opsahl, A.C.,Boucher, G.G.,Birnbaum, M.J.,DaSilva-Jardine, P.,Rolph, T.; Selective Activation of AMPK beta 1-Containing Isoforms Improves Kidney Function in a Rat Model of Diabetic Nephropathy.; J. Pharmacol. Exp. Ther., 361:303-311, 2017; PubMed: 28289077; DOI: 10.1124/jpet.116.237925

Experimental method

X-RAY DIFFRACTION (3.46 Å)