5T5T

AMPK bound to allosteric activator

Summary for 5T5T

Descriptor5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... (9 entities in total)
Functional Keywordsampk, kinase, allostery, activator, transferase
Biological sourceRattus norvegicus (Rat)
Cellular locationCytoplasm  P54645
Total number of polymer chains3
Total molecular weight120500.96
Authors
Calabrese, M.F.,Kurumbail, R.G. (deposition date: 2016-08-31, release date: 2017-03-29, Last modification date: 2017-04-26)
Primary citation
Salatto, C.T.,Miller, R.A.,Cameron, K.O.,Cokorinos, E.,Reyes, A.,Ward, J.,Calabrese, M.F.,Kurumbail, R.G.,Rajamohan, F.,Kalgutkar, A.S.,Tess, D.A.,Shavnya, A.,Genung, N.E.,Edmonds, D.J.,Jatkar, A.,Maciejewski, B.S.,Amaro, M.,Gandhok, H.,Monetti, M.,Cialdea, K.,Bollinger, E.,Kreeger, J.M.,Coskran, T.M.,Opsahl, A.C.,Boucher, G.G.,Birnbaum, M.J.,DaSilva-Jardine, P.,Rolph, T.
Selective Activation of AMPK beta 1-Containing Isoforms Improves Kidney Function in a Rat Model of Diabetic Nephropathy.
J. Pharmacol. Exp. Ther., 361:303-311, 2017
PubMed: 28289077 (PDB entries with the same primary citation)
DOI: 10.1124/jpet.116.237925
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.46 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.24830.2%5.3%3.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution