5T3D

Crystal structure of holo-EntF a nonribosomal peptide synthetase in the thioester-forming conformation

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5T3D の概要

• エントリーDOI: 10.2210/pdb5t3d/pdb
• 分子名称: Enterobactin synthase component F, 5'-({[(2R,3S)-3-amino-4-hydroxy-2-{[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl]sulfanyl}butyl]sulfonyl}amino)-5'-deoxyadenosine (3 entities in total)
• 機能のキーワード: nonribosomal peptide synthetase, nrps, condensation, adenylation, pcp, thioesterase, phosphopantetheine, biosynthetic protein
• 由来する生物種: Escherichia coli (strain K12)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 143087.04

構造登録者

Miller, B.R.,Drake, E.J.,Sundlov, J.A.,Gulick, A.M. (登録日: 2016-08-25, 公開日: 2016-09-21, 最終更新日: 2019-12-25)

• 主引用文献: Drake, E.J.,Miller, B.R.,Shi, C.,Tarrasch, J.T.,Sundlov, J.A.,Allen, C.L.,Skiniotis, G.,Aldrich, C.C.,Gulick, A.M.; Structures of two distinct conformations of holo-non-ribosomal peptide synthetases.; Nature, 529:235-238, 2016; PubMed: 26762461; DOI: 10.1038/nature16163

実験手法

X-RAY DIFFRACTION (2.8 Å)