5T2W

Structure of thymine DNA glycosylase bound to substrate analog 2'-F-5-formyl-dC

Summary for 5T2W

• Entry DOI: 10.2210/pdb5t2w/pdb
• Descriptor: G/T mismatch-specific thymine DNA glycosylase, DNA (28-MER), DNA (27-MER), ... (4 entities in total)
• Functional Keywords: protein-dna complex, hydrolase-dna complex, hydrolase/dna
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus : Q13569
• Total number of polymer chains: 3
• Total formula weight: 43118.09

Authors

Pidugu, L.S.,Pozharski, E.,Drohat, A.C. (deposition date: 2016-08-24, release date: 2016-11-09, Last modification date: 2023-10-04)

• Primary citation: Pidugu, L.S.,Flowers, J.W.,Coey, C.T.,Pozharski, E.,Greenberg, M.M.,Drohat, A.C.; Structural Basis for Excision of 5-Formylcytosine by Thymine DNA Glycosylase.; Biochemistry, 55:6205-6208, 2016; PubMed: 27805810; DOI: 10.1021/acs.biochem.6b00982

Experimental method

X-RAY DIFFRACTION (2.2 Å)