5T1U

Aminomethyl-Derived Beta Secretase (BACE1) Inhibitors: Engaging Gly230 without an Anilide Functionality

Summary for 5T1U

• Entry DOI: 10.2210/pdb5t1u/pdb
• Related: 5T1W
• Descriptor: Beta-secretase 1, (4S)-4-[2,4-difluoro-5-({[1-(trifluoromethyl)cyclopropyl]amino}methyl)phenyl]-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine, IODIDE ION, ... (5 entities in total)
• Functional Keywords: beta secretase, alzheimer's, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Membrane; Single-pass type I membrane protein: P56817
• Total number of polymer chains: 1
• Total formula weight: 47325.22

Authors

Parris, K.D.,Vajdos, F. (deposition date: 2016-08-22, release date: 2017-01-11, Last modification date: 2023-10-04)

• Primary citation: Butler, C.R.,Ogilvie, K.,Martinez-Alsina, L.,Barreiro, G.,Beck, E.M.,Nolan, C.E.,Atchison, K.,Benvenuti, E.,Buzon, L.,Doran, S.,Gonzales, C.,Helal, C.J.,Hou, X.,Hsu, M.H.,Johnson, E.F.,Lapham, K.,Lanyon, L.,Parris, K.,O'Neill, B.T.,Riddell, D.,Robshaw, A.,Vajdos, F.,Brodney, M.A.; Aminomethyl-Derived Beta Secretase (BACE1) Inhibitors: Engaging Gly230 without an Anilide Functionality.; J. Med. Chem., 60:386-402, 2017; PubMed: 27997172; DOI: 10.1021/acs.jmedchem.6b01451

Experimental method

X-RAY DIFFRACTION (1.78 Å)