5SYZ

Human Liver Receptor Homologue-1 (LRH-1) Bound to a RJW100 stereoisomer and a Fragment of TIF-2

Summary for 5SYZ

Entry DOI	10.2210/pdb5syz/pdb
Descriptor	Nuclear receptor subfamily 5 group A member 2, Nuclear receptor coactivator 2, (1S,3aR,6aR)-5-hexyl-4-phenyl-3a-(1-phenylethenyl)-1,2,3,3a,6,6a-hexahydropentalen-1-ol, ... (4 entities in total)
Functional Keywords	nuclear receptor, agonist, coactivator, nuclear protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	30169.84
Authors	Ortlund, E.A.,Mays, S.G. (deposition date: 2016-08-12, release date: 2016-10-12, Last modification date: 2023-10-04)
Primary citation	Mays, S.G.,Okafor, C.D.,Whitby, R.J.,Goswami, D.,Stec, J.,Flynn, A.R.,Dugan, M.C.,Jui, N.T.,Griffin, P.R.,Ortlund, E.A. Crystal Structures of the Nuclear Receptor, Liver Receptor Homolog 1, Bound to Synthetic Agonists. J. Biol. Chem., 291:25281-25291, 2016 Cited by PubMed: 27694446 DOI: 10.1074/jbc.M116.753541 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9261 Å)

Structure validation