5SXM

WDR5 in complex with MLL Win motif peptidomimetic

Summary for 5SXM

• Entry DOI: 10.2210/pdb5sxm/pdb
• Descriptor: WD repeat-containing protein 5, ACE-ALA-ARG-THR-GLU-VAL-TYR-NH2 (3 entities in total)
• Functional Keywords: beta propeller, wd40 repeat, transcription regulator, scaffold, transcription
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 70650.01

Authors

Alicea-Velazquez, N.L.,Shinsky, S.A.,Cosgrove, M.S. (deposition date: 2016-08-09, release date: 2016-09-07, Last modification date: 2023-10-04)

• Primary citation: Alicea-Velazquez, N.L.,Shinsky, S.A.,Loh, D.M.,Lee, J.H.,Skalnik, D.G.,Cosgrove, M.S.; Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.; J.Biol.Chem., 291:22357-22372, 2016; PubMed: 27563068; DOI: 10.1074/jbc.M116.752626

Experimental method

X-RAY DIFFRACTION (2 Å)