5SXM

WDR5 in complex with MLL Win motif peptidomimetic

5SXM の概要

• エントリーDOI: 10.2210/pdb5sxm/pdb
• 分子名称: WD repeat-containing protein 5, ACE-ALA-ARG-THR-GLU-VAL-TYR-NH2 (3 entities in total)
• 機能のキーワード: beta propeller, wd40 repeat, transcription regulator, scaffold, transcription
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 70650.01

構造登録者

Alicea-Velazquez, N.L.,Shinsky, S.A.,Cosgrove, M.S. (登録日: 2016-08-09, 公開日: 2016-09-07, 最終更新日: 2023-10-04)

• 主引用文献: Alicea-Velazquez, N.L.,Shinsky, S.A.,Loh, D.M.,Lee, J.H.,Skalnik, D.G.,Cosgrove, M.S.; Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.; J.Biol.Chem., 291:22357-22372, 2016; PubMed: 27563068; DOI: 10.1074/jbc.M116.752626

実験手法

X-RAY DIFFRACTION (2 Å)