5SW4 の概要
| エントリーDOI | 10.2210/pdb5sw4/pdb |
| 関連するPDBエントリー | 5L02 5L05 5SW5 5SW6 5SX0 5SX1 5SX2 5SX3 5SX6 5SX7 5SXQ 5SXR 5SXS 5SXT 5SXX 5SYH 5SYI 5SYJ 5SYK 5SYL 5SYU 5SYV 5SYW 5SYX 5SYY |
| 分子名称 | Catalase-peroxidase, PROTOPORPHYRIN IX CONTAINING FE, SODIUM ION, ... (8 entities in total) |
| 機能のキーワード | catalase, peroxidase, ph change, molecular switch, oxidoreductase |
| 由来する生物種 | Burkholderia pseudomallei (strain 1710b) |
| タンパク質・核酸の鎖数 | 2 |
| 化学式量合計 | 161237.67 |
| 構造登録者 | |
| 主引用文献 | Carpena, X.,Wiseman, B.,Deemagarn, T.,Singh, R.,Switala, J.,Ivancich, A.,Fita, I.,Loewen, P.C. A molecular switch and electronic circuit modulate catalase activity in catalase-peroxidases. EMBO Rep., 6:1156-1162, 2005 Cited by PubMed Abstract: The catalase reaction of catalase-peroxidases involves catalase-specific features built into a peroxidase core. An arginine, 20 A from the active-site heme, acts as a molecular switch moving between two conformations, one that activates heme oxidation and one that activates oxoferryl heme reduction by H(2)O(2), facilitating the catalatic pathway in a peroxidase. The influence of the arginine is imparted to the heme through its association with or dissociation from a tyrosinate that modulates reactivity through a Met-Tyr-Trp crosslinked adduct and a pi electron interaction of the heme with the adduct Trp. PubMed: 16211084主引用文献が同じPDBエントリー |
| 実験手法 | X-RAY DIFFRACTION (1.9 Å) |
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