5SSW

DHFR:NADP+:FOL complex at 270 K (multi-crystal)

5SSW の概要

• エントリーDOI: 10.2210/pdb5ssw/pdb
• Group deposition: DHFR:NADP+:FOL complex at 270 K (G_1002242)
• 分子名称: Dihydrofolate reductase, FOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
• 機能のキーワード: dihydrofolate reductase, oxidoreductase
• 由来する生物種: Escherichia coli K-12
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 19400.95

構造登録者

Greisman, J.B.,Dalton, K.M.,Brookner, D.E.,Hekstra, D.R. (登録日: 2022-07-03, 公開日: 2023-08-23, 最終更新日: 2024-07-24)

• 主引用文献: Greisman, J.B.,Dalton, K.M.,Brookner, D.E.,Klureza, M.A.,Sheehan, C.J.,Kim, I.S.,Henning, R.W.,Russi, S.,Hekstra, D.R.; Perturbative diffraction methods resolve a conformational switch that facilitates a two-step enzymatic mechanism.; Proc.Natl.Acad.Sci.USA, 121:e2313192121-e2313192121, 2024; PubMed: 38386706; DOI: 10.1073/pnas.2313192121

実験手法

X-RAY DIFFRACTION (1.06 Å)