5SKU

CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 10 IN COMPLEX WITH c4(cc(c(c1nc(c(C)o1)CCOc2ccc(c3ccccc23)C[C@@H](C(O)=O)OC)cc4)OCC)F, micromolar IC50=0.095357

Summary for 5SKU

• Entry DOI: 10.2210/pdb5sku/pdb
• Group deposition: To be published (G_1002229)
• Descriptor: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: phosphodiesterase, pde10, hydrolase, schizophrenia, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 159985.76

Authors

Joseph, C.,Benz, J.,Flohr, A.,Binggeli, A.,Rudolph, M.G. (deposition date: 2022-02-01, release date: 2022-10-12, Last modification date: 2024-10-16)

• Primary citation: Flohr, A.,Schlatter, D.,Kuhn, B.,Rudolph, M.G.; Crystal Structure of a human phosphodiesterase 10 complex; To be published,

Experimental method

X-RAY DIFFRACTION (2.2 Å)