5SJR

CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 10 IN COMPLEX WITH c4(c(c1ccc(cc1)c2ccccc2OCC)nc3ccc(cc3c4N[C@@H](C(O)=O)C)F)C#N, micromolar IC50=0.0015665

5SJR の概要

• エントリーDOI: 10.2210/pdb5sjr/pdb
• Group deposition: To be published (G_1002229)
• 分子名称: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, N-[3-cyano-2-(2'-ethoxy[1,1'-biphenyl]-4-yl)-6-fluoroquinolin-4-yl]-D-alanine, ZINC ION, ... (7 entities in total)
• 機能のキーワード: phosphodiesterase, pde10, hydrolase, schizophrenia, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 160053.23

構造登録者

Joseph, C.,Benz, J.,Flohr, A.,Koerner, M.,Rudolph, M.G. (登録日: 2022-02-01, 公開日: 2022-10-12, 最終更新日: 2024-10-16)

• 主引用文献: Flohr, A.,Schlatter, D.,Kuhn, B.,Rudolph, M.G.; Crystal Structure of a human phosphodiesterase 10 complex; To be published,

実験手法

X-RAY DIFFRACTION (2.1 Å)