5SF1

Crystal Structure of human phosphodiesterase 10 in complex with 2-(difluoromethyl)-3-methyl-6-[2-(1-methyl-4-phenylimidazol-2-yl)ethynyl]imidazo[1,2-b]pyridazine

5SF1 の概要

• エントリーDOI: 10.2210/pdb5sf1/pdb
• Group deposition: Exploiting Structural Data for Improved On-Target Prediction in Lead Optimization (G_1002226)
• 分子名称: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, (4S)-2-(difluoromethyl)-3-methyl-6-[(1-methyl-4-phenyl-1H-imidazol-2-yl)ethynyl]imidazo[1,2-b]pyridazine, ZINC ION, ... (5 entities in total)
• 機能のキーワード: phosphodiesterase, pde10, hydrolase, schizophrenia, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 159465.12

構造登録者

Joseph, C.,Groebke-Zbinden, K.,Benz, J.,Schlatter, D.,Rudolph, M.G. (登録日: 2022-01-21, 公開日: 2022-10-12, 最終更新日: 2024-04-03)

• 主引用文献: Tosstorff, A.,Rudolph, M.G.,Cole, J.C.,Reutlinger, M.,Kramer, C.,Schaffhauser, H.,Nilly, A.,Flohr, A.,Kuhn, B.; A high quality, industrial data set for binding affinity prediction: performance comparison in different early drug discovery scenarios.; J.Comput.Aided Mol.Des., 36:753-765, 2022; PubMed: 36153472; DOI: 10.1007/s10822-022-00478-x

実験手法

X-RAY DIFFRACTION (2.11 Å)