5SCX

Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-1190 (racemic mixture)

5SCX の概要

• エントリーDOI: 10.2210/pdb5scx/pdb
• Group deposition: DHFR structures, SSGCID (G_1002223)
• 分子名称: Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (2R)-2-[(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)methyl]-3,3-difluoropropanoic acid, ... (6 entities in total)
• 機能のキーワード: mycobacterium tuberculosis, dhfr, nadp, folate, oxidoreductase-oxidoreductase inhibitor complex, structural genomics, seattle structural genomics center for infectious disease, ssgcid, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Mycobacterium tuberculosis H37Rv
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 21071.24

構造登録者

Seattle Structural Genomics Center for Infectious Disease (SSGCID) (登録日: 2021-12-20, 公開日: 2022-02-09, 最終更新日: 2024-05-22)

• 主引用文献: Mayclin, S.J.,Conrady, D.G.,Lorimer, D.D.; Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-1190 (racemic mixture); to be published,

実験手法

X-RAY DIFFRACTION (1.3 Å)