5SCV

Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-889

5SCV の概要

• エントリーDOI: 10.2210/pdb5scv/pdb
• Group deposition: DHFR structures, SSGCID (G_1002223)
• 分子名称: Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 6-ethyl-5-(4-{3-[3-(1H-tetrazol-5-yl)propyl]phenoxy}butoxy)pyrimidine-2,4-diamine, ... (5 entities in total)
• 機能のキーワード: mycobacterium tuberculosis, dhfr, nadp, folate, oxidoreductase-oxidoreductase inhibitor complex, structural genomics, seattle structural genomics center for infectious disease, ssgcid, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Mycobacterium tuberculosis H37Rv
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 42047.42

構造登録者

Seattle Structural Genomics Center for Infectious Disease (SSGCID) (登録日: 2021-12-20, 公開日: 2022-02-09, 最終更新日: 2024-05-22)

• 主引用文献: Mayclin, S.J.,Fairman, J.W.,Dranow, D.M.,Conrady, D.G.,Fox III, D.,Lukacs, C.M.,Lorimer, D.D.,Horanyi, P.S.,Edwards, T.E.,Abendroth, J.; Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-889; to be published,

実験手法

X-RAY DIFFRACTION (1.55 Å)