5SCV
Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-889
5SCV の概要
エントリーDOI | 10.2210/pdb5scv/pdb |
Group deposition | DHFR structures, SSGCID (G_1002223) |
分子名称 | Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 6-ethyl-5-(4-{3-[3-(1H-tetrazol-5-yl)propyl]phenoxy}butoxy)pyrimidine-2,4-diamine, ... (5 entities in total) |
機能のキーワード | mycobacterium tuberculosis, dhfr, nadp, folate, oxidoreductase-oxidoreductase inhibitor complex, structural genomics, seattle structural genomics center for infectious disease, ssgcid, oxidoreductase/oxidoreductase inhibitor |
由来する生物種 | Mycobacterium tuberculosis H37Rv |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 42047.42 |
構造登録者 | Seattle Structural Genomics Center for Infectious Disease (SSGCID) (登録日: 2021-12-20, 公開日: 2022-02-09, 最終更新日: 2024-05-22) |
主引用文献 | Mayclin, S.J.,Fairman, J.W.,Dranow, D.M.,Conrady, D.G.,Fox III, D.,Lukacs, C.M.,Lorimer, D.D.,Horanyi, P.S.,Edwards, T.E.,Abendroth, J. Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-889 to be published, |
実験手法 | X-RAY DIFFRACTION (1.55 Å) |
構造検証レポート
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