5SCQ
Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-614
Summary for 5SCQ
Entry DOI | 10.2210/pdb5scq/pdb |
Group deposition | DHFR structures, SSGCID (G_1002223) |
Descriptor | Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N-[2-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)ethanesulfonyl]acetamide, ... (4 entities in total) |
Functional Keywords | mycobacterium tuberculosis, dhfr, nadp, folate, oxidoreductase-oxidoreductase inhibitor complex, structural genomics, seattle structural genomics center for infectious disease, ssgcid, oxidoreductase/oxidoreductase inhibitor |
Biological source | Mycobacterium tuberculosis H37Rv |
Total number of polymer chains | 1 |
Total formula weight | 21013.28 |
Authors | Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2021-12-20, release date: 2022-02-09, Last modification date: 2024-05-22) |
Primary citation | Mayclin, S.J.,Fairman, J.W.,Dranow, D.M.,Conrady, D.G.,Fox III, D.,Lukacs, C.M.,Lorimer, D.D.,Horanyi, P.S.,Edwards, T.E.,Abendroth, J. Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-614 to be published, |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
Download full validation report