5SB8

Tubulin-maytansinoid-3-complex

5SB8 の概要

• エントリーDOI: 10.2210/pdb5sb8/pdb
• Group deposition: T2R-TTL-maytansinoid structures (G_1002215)
• 分子名称: Tubulin alpha-1B chain, IMIDAZOLE, (1S,2R,3S,5S,6S,16E,18E,20R)-11-chloro-6-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1~10,14~.0~3,5~]hexacosa-10(26),11,13,16,18,21-hexaene-8,23-dione, ... (13 entities in total)
• 機能のキーワード: cell cycle, tubulin fold, cytoskeleton, microtubule
• 由来する生物種: Rattus norvegicus (Rat); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 265122.41

構造登録者

Marzullo, P.,Boiarska, Z.,Perez-Pena, H.,Abel, A.-C.,Alvarez-Bernad, B.,Lucena-Agell, D.,Vasile, F.,Sironi, M.,Steinmetz, M.O.,Prota, A.E.,Diaz, J.F.,Pieraccini, S.,Passarella, D. (登録日: 2021-07-20, 公開日: 2021-12-08, 最終更新日: 2024-05-22)

• 主引用文献: Marzullo, P.,Boiarska, Z.,Perez-Pena, H.,Abel, A.C.,Alvarez-Bernad, B.,Lucena-Agell, D.,Vasile, F.,Sironi, M.,Altmann, K.H.,Prota, A.E.,Diaz, J.F.,Pieraccini, S.,Passarella, D.; Maytansinol Derivatives: Side Reactions as a Chance for New Tubulin Binders.; Chemistry, 28:e202103520-e202103520, 2022; PubMed: 34788896; DOI: 10.1002/chem.202103520

実験手法