5SB0
DDR1, N-[[2-(2-pyridin-3-yloxyethyl)cyclohexyl]methyl]-3-(trifluoromethoxy)benzamide, 1.970A, P212121, Rfree=25.6%
Summary for 5SB0
Entry DOI | 10.2210/pdb5sb0/pdb |
Group deposition | Novel Potent and Highly Selective DDR1 Inhibitors from Structure-guided Drug Design (G_1002213) |
Descriptor | Epithelial discoidin domain-containing receptor 1, IODIDE ION, N-{[(1R,2S)-2-{2-[(pyridin-3-yl)oxy]ethyl}cyclohexyl]methyl}-3-(trifluoromethoxy)benzamide, ... (5 entities in total) |
Functional Keywords | rtk, receptor tyrosine kinase, collagen, discoidin domain;, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 37087.65 |
Authors | Stihle, M.,Richter, H.,Benz, J.,Hochstrasser, R.,Rudolph, M.G. (deposition date: 2021-06-22, release date: 2022-06-29, Last modification date: 2024-04-03) |
Primary citation | Richter, H.,Prunotto, M.,Kuhn, B.,Rudolph, M.G. Crystal Structure of a DDR1 complex To be published, |
Experimental method | X-RAY DIFFRACTION (1.97 Å) |
Structure validation
Download full validation report