5SB0

DDR1, N-[[2-(2-pyridin-3-yloxyethyl)cyclohexyl]methyl]-3-(trifluoromethoxy)benzamide, 1.970A, P212121, Rfree=25.6%

5SB0 の概要

• エントリーDOI: 10.2210/pdb5sb0/pdb
• Group deposition: Novel Potent and Highly Selective DDR1 Inhibitors from Structure-guided Drug Design (G_1002213)
• 分子名称: Epithelial discoidin domain-containing receptor 1, IODIDE ION, N-{[(1R,2S)-2-{2-[(pyridin-3-yl)oxy]ethyl}cyclohexyl]methyl}-3-(trifluoromethoxy)benzamide, ... (5 entities in total)
• 機能のキーワード: rtk, receptor tyrosine kinase, collagen, discoidin domain;, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37087.65

構造登録者

Stihle, M.,Richter, H.,Benz, J.,Hochstrasser, R.,Rudolph, M.G. (登録日: 2021-06-22, 公開日: 2022-06-29, 最終更新日: 2024-04-03)

• 主引用文献: Richter, H.,Prunotto, M.,Kuhn, B.,Rudolph, M.G.; Crystal Structure of a DDR1 complex; To be published,

実験手法

X-RAY DIFFRACTION (1.97 Å)