5SAZ

DDR1, 3-chloro-N-[4-chloro-3-(1H-pyrrolo[2,3-b]pyridin-5-ylcarbamoyl)phenyl]-4-(2-hydroxyethylamino)benzamide, 1.802A, P212121, Rfree=22.2%

5SAZ の概要

• エントリーDOI: 10.2210/pdb5saz/pdb
• Group deposition: Novel Potent and Highly Selective DDR1 Inhibitors from Structure-guided Drug Design (G_1002213)
• 分子名称: Epithelial discoidin domain-containing receptor 1, 2-chloro-5-{3-chloro-4-[(2-hydroxyethyl)amino]benzamido}-N-(1H-pyrrolo[2,3-b]pyridin-5-yl)benzamide, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (5 entities in total)
• 機能のキーワード: rtk, receptor tyrosine kinase, collagen, discoidin domain;, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37217.88

構造登録者

Stihle, M.,Richter, H.,Benz, J.,Hochstrasser, R.,Rudolph, M.G. (登録日: 2021-06-22, 公開日: 2022-06-29, 最終更新日: 2024-04-03)

• 主引用文献: Richter, H.,Prunotto, M.,Kuhn, B.,Rudolph, M.G.; Crystal Structure of a DDR1 complex; To be published,

実験手法

X-RAY DIFFRACTION (1.8 Å)