5SAW

DDR1, 2-[3-(2-pyridin-3-ylethynyl)phenyl]-N-[3-(trifluoromethyl)phenyl]acetamide, 1.601A, P212121, Rfree=22.6%

5SAW の概要

• エントリーDOI: 10.2210/pdb5saw/pdb
• Group deposition: Novel Potent and Highly Selective DDR1 Inhibitors from Structure-guided Drug Design (G_1002213)
• 分子名称: Epithelial discoidin domain-containing receptor 1, 2-{3-[(pyridin-3-yl)ethynyl]phenyl}-N-[3-(trifluoromethyl)phenyl]acetamide, IODIDE ION, ... (4 entities in total)
• 機能のキーワード: rtk, receptor tyrosine kinase, collagen, discoidin domain;, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38152.26

構造登録者

Stihle, M.,Richter, H.,Benz, J.,Hochstrasser, R.,Rudolph, M.G. (登録日: 2021-06-22, 公開日: 2022-06-29, 最終更新日: 2024-04-03)

• 主引用文献: Richter, H.,Prunotto, M.,Kuhn, B.,Rudolph, M.G.; Crystal Structure of a DDR1 complex; To be published,

実験手法

X-RAY DIFFRACTION (1.601 Å)