5SAB

PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 NendoU in complex with Z31504642

5SAB の概要

• エントリーDOI: 10.2210/pdb5sab/pdb
• Group deposition: PanDDA analysis group deposition (G_1002199)
• 分子名称: Uridylate-specific endoribonuclease, CITRIC ACID, 2-methoxy-N-phenylacetamide, ... (4 entities in total)
• 機能のキーワード: sgc - diamond i04-1 fragment screening, pandda, xchemexplorer, nsp15, nendou, sars-cov-2, sars, covid, covid19, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 78774.51

構造登録者

Godoy, A.S.,Douangamath, A.,Nakamura, A.M.,Dias, A.,Krojer, T.,Noske, G.D.,Gawiljuk, V.O.,Fernandes, R.S.,Fairhead, M.,Powell, A.,Dunnet, L.,Aimon, A.,Fearon, D.,Brandao-Neto, J.,Skyner, R.,von Delft, F.,Oliva, G. (登録日: 2021-05-19, 公開日: 2021-06-09, 最終更新日: 2023-05-10)

• 主引用文献: Godoy, A.S.,Nakamura, A.M.,Douangamath, A.,Song, Y.,Noske, G.D.,Gawriljuk, V.O.,Fernandes, R.S.,Pereira, H.D.M.,Oliveira, K.I.Z.,Fearon, D.,Dias, A.,Krojer, T.,Fairhead, M.,Powell, A.,Dunnet, L.,Brandao-Neto, J.,Skyner, R.,Chalk, R.,Bajusz, D.,Bege, M.,Borbas, A.,Keseru, G.M.,von Delft, F.,Oliva, G.; Allosteric regulation and crystallographic fragment screening of SARS-CoV-2 NSP15 endoribonuclease.; Nucleic Acids Res., 2023; PubMed: 37115000; DOI: 10.1093/nar/gkad314

実験手法

X-RAY DIFFRACTION (2.486 Å)