5S94

PanDDA analysis group deposition -- Crystal Structure of PHIP in complex with Z198194396 synthetic derivative

5S94 の概要

• エントリーDOI: 10.2210/pdb5s94/pdb
• Group deposition: PanDDA analysis group deposition (G_1002190)
• 分子名称: PH-interacting protein, N-(cyclopropylmethyl)-4-(5-methylfuran-2-carbonyl)piperazine-1-carboxamide (3 entities in total)
• 機能のキーワード: sgc - diamond i04-1 fragment screening, pandda, xchemexplorer, robotic chemistry, crystal soaking, reaction crudes, signaling protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 17919.21

構造登録者

Grosjean, H.,Aimon, A.,Hassel-Hart , S.,Krojer, T.,Talon, R.,Douangamath, A.,Koekemoer, L.,Biggin, P.C.,Spencer, J.,von Delft, F. (登録日: 2021-01-22, 公開日: 2021-02-17, 最終更新日: 2024-03-06)

• 主引用文献: Grosjean, H.,Aimon, A.,Hart , S.,Krojer, T.,Talon, R.,Douangamath, A.,Koekemoer, L.,Biggin, P.C.,Spencer, J.,von Delft, F.; Crystal Structures of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) in space group C2 soaked with crude reaction mixtures; To Be Published,

実験手法

X-RAY DIFFRACTION (1.2 Å)