5RY0
INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z275165822
Summary for 5RY0
Entry DOI | 10.2210/pdb5ry0/pdb |
Group deposition | INPP5D PanDDA analysis group deposition (G_1002180) |
Descriptor | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1, 1-[4-(4-chlorophenyl)piperazin-1-yl]ethan-1-one, DIMETHYL SULFOXIDE, ... (4 entities in total) |
Functional Keywords | sgc - diamond i04-1 fragment screening, pandda, xchemexplorer, ship1, alzheimers, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 53350.69 |
Authors | Bradshaw, W.J.,Newman, J.A.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Gileadi, O. (deposition date: 2020-10-30, release date: 2020-11-11, Last modification date: 2024-02-14) |
Primary citation | Bradshaw, W.J.,Kennedy, E.C.,Moreira, T.,Smith, L.A.,Chalk, R.,Katis, V.L.,Benesch, J.L.P.,Brennan, P.E.,Murphy, E.J.,Gileadi, O. Regulation of inositol 5-phosphatase activity by the C2 domain of SHIP1 and SHIP2. Structure, 2024 Cited by PubMed: 38309262DOI: 10.1016/j.str.2024.01.005 PDB entries with the same primary citation |
Experimental method |
Structure validation
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