5RWS
INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z1478435544
5RWS の概要
エントリーDOI | 10.2210/pdb5rws/pdb |
Group deposition | INPP5D PanDDA analysis group deposition (G_1002180) |
分子名称 | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1, 5-methyl-N-[(pyridin-4-yl)methyl]pyridin-3-amine, DIMETHYL SULFOXIDE, ... (5 entities in total) |
機能のキーワード | sgc - diamond i04-1 fragment screening, pandda, xchemexplorer, ship1, alzheimers, hydrolase |
由来する生物種 | Homo sapiens (human) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 53406.20 |
構造登録者 | Bradshaw, W.J.,Newman, J.A.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Gileadi, O. (登録日: 2020-10-30, 公開日: 2020-11-11, 最終更新日: 2024-02-14) |
主引用文献 | Bradshaw, W.J.,Kennedy, E.C.,Moreira, T.,Smith, L.A.,Chalk, R.,Katis, V.L.,Benesch, J.L.P.,Brennan, P.E.,Murphy, E.J.,Gileadi, O. Regulation of inositol 5-phosphatase activity by the C2 domain of SHIP1 and SHIP2. Structure, 2024 Cited by PubMed: 38309262DOI: 10.1016/j.str.2024.01.005 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.28 Å) |
構造検証レポート
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