5RWD

INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z1675346324

Summary for 5RWD

Entry DOI	10.2210/pdb5rwd/pdb
Group deposition	INPP5D PanDDA analysis group deposition (G_1002180)
Descriptor	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1, trans-3-[(2,6-dimethylpyrimidin-4-yl)(methyl)amino]cyclobutan-1-ol, DIMETHYL SULFOXIDE, ... (4 entities in total)
Functional Keywords	sgc - diamond i04-1 fragment screening, pandda, xchemexplorer, ship1, alzheimers, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	53526.52
Authors	Bradshaw, W.J.,Newman, J.A.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Gileadi, O. (deposition date: 2020-10-30, release date: 2020-11-11, Last modification date: 2024-02-14)
Primary citation	Bradshaw, W.J.,Kennedy, E.C.,Moreira, T.,Smith, L.A.,Chalk, R.,Katis, V.L.,Benesch, J.L.P.,Brennan, P.E.,Murphy, E.J.,Gileadi, O. Regulation of inositol 5-phosphatase activity by the C2 domain of SHIP1 and SHIP2. Structure, 2024 Cited by PubMed: 38309262 DOI: 10.1016/j.str.2024.01.005 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.29 Å)

Structure validation