5R8B
PanDDA analysis group deposition INTERLEUKIN-1 BETA -- Fragment Z2027049478 in complex with INTERLEUKIN-1 BETA
5R8B の概要
エントリーDOI | 10.2210/pdb5r8b/pdb |
Group deposition | PanDDA analysis group deposition INTERLEUKIN-1 BETA (G_1002139) |
分子名称 | Interleukin-1 beta, SULFATE ION, 5-(1,3-thiazol-2-yl)-1H-1,2,4-triazole, ... (4 entities in total) |
機能のキーワード | il-1 beta, signaling protein, sgc - diamond i04-1 fragment screening, pandda, xchemexplorer |
由来する生物種 | Homo sapiens (Human) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 17892.31 |
構造登録者 | |
主引用文献 | Nichols, C.,Ng, J.,Keshu, A.,Kelly, G.,Conte, M.R.,Marber, M.S.,Fraternali, F.,De Nicola, G.F. Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63:7559-7568, 2020 Cited by PubMed: 32543856DOI: 10.1021/acs.jmedchem.0c00403 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.49 Å) |
構造検証レポート
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