5QUA

Crystal Structure of swapped human Nck SH3.1 domain, 1.5A, C2221

5QUA の概要

• エントリーDOI: 10.2210/pdb5qua/pdb
• Group deposition: structural plasticity of the Nck1-SH3.1 domain (G_1002110)
• 分子名称: Cytoplasmic protein NCK1 (2 entities in total)
• 機能のキーワード: sh3 domain, adaptor, peptide binding, signaling protein, domain swap
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 20598.82

構造登録者

Rudolph, M.G. (登録日: 2019-12-13, 公開日: 2020-02-12, 最終更新日: 2024-04-03)

• 主引用文献: Richter, K.,Rufer, A.C.,Muller, M.,Burger, D.,Casagrande, F.,Grossenbacher, T.,Huber, S.,Hug, M.N.,Koldewey, P.,D'Osualdo, A.,Schlatter, D.,Stoll, T.,Rudolph, M.G.; Small molecule AX-024 reduces T cell proliferation independently of CD3ε/Nck1 interaction, which is governed by a domain swap in the Nck1-SH3.1 domain.; J.Biol.Chem., 295:7849-7864, 2020; PubMed: 32317279; DOI: 10.1074/jbc.RA120.012788

実験手法

X-RAY DIFFRACTION (1.51 Å)