5QU6
Crystal Structure of swapped human Nck SH3.1 domain, 1.8A, triclinic
Summary for 5QU6
| Entry DOI | 10.2210/pdb5qu6/pdb |
| Group deposition | structural plasticity of the Nck1-SH3.1 domain (G_1002110) |
| Descriptor | Cytoplasmic protein NCK1 (2 entities in total) |
| Functional Keywords | sh3 domain, adaptor, peptide binding, signaling protein, domain swap |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 28 |
| Total formula weight | 288383.48 |
| Authors | Rudolph, M.G. (deposition date: 2019-12-13, release date: 2020-02-12, Last modification date: 2024-04-03) |
| Primary citation | Richter, K.,Rufer, A.C.,Muller, M.,Burger, D.,Casagrande, F.,Grossenbacher, T.,Huber, S.,Hug, M.N.,Koldewey, P.,D'Osualdo, A.,Schlatter, D.,Stoll, T.,Rudolph, M.G. Small molecule AX-024 reduces T cell proliferation independently of CD3ε/Nck1 interaction, which is governed by a domain swap in the Nck1-SH3.1 domain. J.Biol.Chem., 295:7849-7864, 2020 Cited by PubMed: 32317279DOI: 10.1074/jbc.RA120.012788 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.816 Å) |
Structure validation
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