5QJ2

CRYSTAL STRUCTURE OF MYELOPEROXIDASE SUBFORM C (MPO) OMPLEX WITH COMPOUND-20 AKA 7-((3-(1-METHYL-1H-PYRAZOL-3- YL)BENZYL)OXY)- 1H-[1,2,3]TRIAZOLO[4,5-B]PYRIDIN-5-AMINE

Summary for 5QJ2

Entry DOI	10.2210/pdb5qj2/pdb
Group deposition	MPO (G_1002056)
Descriptor	Myeloperoxidase, CHLORIDE ION, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total)
Functional Keywords	myeloperoxidase, metal binding protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	8
Total formula weight	272400.99
Authors	Khan, J.A. (deposition date: 2018-09-26, release date: 2019-02-06, Last modification date: 2021-05-12)
Primary citation	Wurtz, N.R.,Viet, A.,Shaw, S.A.,Dilger, A.,Valente, M.N.,Khan, J.A.,Jusuf, S.,Narayanan, R.,Fernando, G.,Lo, F.,Liu, X.,Locke, G.A.,Kopcho, L.,Abell, L.M.,Sleph, P.,Basso, M.,Zhao, L.,Wexler, R.R.,Duclos, F.,Kick, E.K. Potent Triazolopyridine Myeloperoxidase Inhibitors. ACS Med Chem Lett, 9:1175-1180, 2018 Cited by PubMed: 30613322 DOI: 10.1021/acsmedchemlett.8b00308 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.82 Å)

Structure validation