5QIL

TGF-BETA RECEPTOR TYPE 1 KINASE DOMAIN (T204D) IN COMPLEX WITH N-{4-[3-(6-METHOXYPYRIDIN-3-YL)-1H-PYRROLO[3,2-B]PYRIDIN-2-YL]PYRIDIN-2-YL}ACETAMIDE

5QIL の概要

• エントリーDOI: 10.2210/pdb5qil/pdb
• Group deposition: TGFBR (G_1002052)
• 分子名称: TGF-beta receptor type-1, N-{4-[3-(6-methoxypyridin-3-yl)-1H-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl}acetamide (3 entities in total)
• 機能のキーワード: alk5, sb431542, kinase domain, transferase-transferase inhibitor complex, transferase, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35524.85

構造登録者

Sheriff, S. (登録日: 2018-08-05, 公開日: 2018-10-31, 最終更新日: 2024-03-06)

• 主引用文献: Zhang, Y.,Zhao, Y.,Tebben, A.J.,Sheriff, S.,Ruzanov, M.,Fereshteh, M.P.,Fan, Y.,Lippy, J.,Swanson, J.,Ho, C.P.,Wautlet, B.S.,Rose, A.,Parrish, K.,Yang, Z.,Donnell, A.F.,Zhang, L.,Fink, B.E.,Vite, G.D.,Augustine-Rauch, K.,Fargnoli, J.,Borzilleri, R.M.; Discovery of 4-Azaindole Inhibitors of TGF beta RI as Immuno-oncology Agents.; ACS Med Chem Lett, 9:1117-1122, 2018; PubMed: 30429955; DOI: 10.1021/acsmedchemlett.8b00357

実験手法

X-RAY DIFFRACTION (1.98 Å)