5QFU
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOOA000487a
Summary for 5QFU
Entry DOI | 10.2210/pdb5qfu/pdb |
Group deposition | PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) (G_1002043) |
Descriptor | Tyrosine-protein phosphatase non-receptor type 1, (1R,4R,5R,6R)-4-methoxy-2-(methylsulfonyl)-2-azabicyclo[3.3.1]nonan-6-ol, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (4 entities in total) |
Functional Keywords | pandda, sgc - diamond i04-1 fragment screening, protein tyrosine phosphatase, ptp, protein tyrosine phosphatase 1b, ptp1b, enzyme, allostery, multiconformer, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 37966.36 |
Authors | Keedy, D.A.,Hill, Z.B.,Biel, J.T.,Kang, E.,Rettenmaier, T.J.,Brandao-Neto, J.,von Delft, F.,Wells, J.A.,Fraser, J.S. (deposition date: 2018-08-30, release date: 2018-10-10, Last modification date: 2024-03-06) |
Primary citation | Keedy, D.A.,Hill, Z.B.,Biel, J.T.,Kang, E.,Rettenmaier, T.J.,Brandao-Neto, J.,Pearce, N.M.,von Delft, F.,Wells, J.A.,Fraser, J.S. An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering. Elife, 7:-, 2018 Cited by PubMed: 29877794DOI: 10.7554/eLife.36307 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.613 Å) |
Structure validation
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