5QFP

PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOMB000293a

5QFP の概要

• エントリーDOI: 10.2210/pdb5qfp/pdb
• Group deposition: PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) (G_1002043)
• 分子名称: Tyrosine-protein phosphatase non-receptor type 1, 3,4,6,7-tetrahydroacridine-1,8(2H,5H)-dione, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (4 entities in total)
• 機能のキーワード: pandda, sgc - diamond i04-1 fragment screening, protein tyrosine phosphatase, ptp, protein tyrosine phosphatase 1b, ptp1b, enzyme, allostery, multiconformer, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37682.95

構造登録者

Keedy, D.A.,Hill, Z.B.,Biel, J.T.,Kang, E.,Rettenmaier, T.J.,Brandao-Neto, J.,von Delft, F.,Wells, J.A.,Fraser, J.S. (登録日: 2018-08-30, 公開日: 2018-10-10, 最終更新日: 2024-03-06)

• 主引用文献: Keedy, D.A.,Hill, Z.B.,Biel, J.T.,Kang, E.,Rettenmaier, T.J.,Brandao-Neto, J.,Pearce, N.M.,von Delft, F.,Wells, J.A.,Fraser, J.S.; An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering.; Elife, 7:-, 2018; PubMed: 29877794; DOI: 10.7554/eLife.36307

実験手法

X-RAY DIFFRACTION (1.771 Å)