5QE8
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000127a
5QE8 の概要
エントリーDOI | 10.2210/pdb5qe8/pdb |
Group deposition | PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) (G_1002043) |
分子名称 | Tyrosine-protein phosphatase non-receptor type 1, N-(4-methoxyphenyl)-N'-pyridin-4-ylurea, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (4 entities in total) |
機能のキーワード | pandda, sgc - diamond i04-1 fragment screening, protein tyrosine phosphatase, ptp, protein tyrosine phosphatase 1b, ptp1b, enzyme, allostery, multiconformer, hydrolase |
由来する生物種 | Homo sapiens (Human) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 38197.49 |
構造登録者 | Keedy, D.A.,Hill, Z.B.,Biel, J.T.,Kang, E.,Rettenmaier, T.J.,Brandao-Neto, J.,von Delft, F.,Wells, J.A.,Fraser, J.S. (登録日: 2018-08-30, 公開日: 2018-10-10, 最終更新日: 2024-03-06) |
主引用文献 | Keedy, D.A.,Hill, Z.B.,Biel, J.T.,Kang, E.,Rettenmaier, T.J.,Brandao-Neto, J.,Pearce, N.M.,von Delft, F.,Wells, J.A.,Fraser, J.S. An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering. Elife, 7:-, 2018 Cited by PubMed: 29877794DOI: 10.7554/eLife.36307 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.813 Å) |
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