5QCD

Crystal structure of human Cathepsin-S with bound ligand

Summary for 5QCD

• Entry DOI: 10.2210/pdb5qcd/pdb
• Group deposition: Ligand binding to Cathepsin S (G_1002040)
• Descriptor: Cathepsin S, {(3S)-7-[(2-chloro-5-{5-(methylsulfonyl)-1-[3-(morpholin-4-yl)propyl]-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl}phenyl)ethynyl]-1,2,3,4-tetrahydroisoquinolin-3-yl}(piperidin-1-yl)methanone, SULFATE ION, ... (4 entities in total)
• Functional Keywords: d3r, cathepsin s, ligand docking, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 25317.84

Authors

Bembenek, S.D.,Ameriks, M.K.,Mirzadegan, T.,Yang, H.,Shao, C.,Burley, S.K. (deposition date: 2017-08-04, release date: 2017-12-20, Last modification date: 2021-11-17)

• Primary citation: Bembenek, S.D.,Ameriks, M.K.,Mirzadegan, T.,Yang, H.,Shao, C.,Burley, S.K.; Crystal structure of human Cathepsin-S with bound ligand; To be published,

Experimental method

X-RAY DIFFRACTION (1.95 Å)