5QAZ
OXA-48 IN COMPLEX WITH COMPOUND 34
5QAZ の概要
エントリーDOI | 10.2210/pdb5qaz/pdb |
Group deposition | A focused fragment library targeting the antibiotic resistance enzyme - oxacillinase-48: synthesis, structural evaluation and inhibitor design (G_1002027) |
分子名称 | Beta-lactamase, 3-(1~{H}-indol-5-yl)benzoic acid, CHLORIDE ION, ... (5 entities in total) |
機能のキーワード | oxacillinase, inhibitor, complex, oxa, antibiotic resistance, beta-lactamase, fragment, hydrolase |
由来する生物種 | Klebsiella pneumoniae |
タンパク質・核酸の鎖数 | 4 |
化学式量合計 | 113989.79 |
構造登録者 | |
主引用文献 | Akhter, S.,Lund, B.A.,Ismael, A.,Langer, M.,Isaksson, J.,Christopeit, T.,Leiros, H.S.,Bayer, A. A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design. Eur J Med Chem, 145:634-648, 2018 Cited by PubMed: 29348071DOI: 10.1016/j.ejmech.2017.12.085 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.2 Å) |
構造検証レポート
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