5QAY
OXA-48 IN COMPLEX WITH COMPOUND 32
Summary for 5QAY
Entry DOI | 10.2210/pdb5qay/pdb |
Group deposition | A focused fragment library targeting the antibiotic resistance enzyme - oxacillinase-48: synthesis, structural evaluation and inhibitor design (G_1002027) |
Descriptor | Beta-lactamase, 3-(1-methylpyrrol-2-yl)benzoic acid, CHLORIDE ION, ... (5 entities in total) |
Functional Keywords | oxacillinase, inhibitor, complex, oxa, antibiotic resistance, beta-lactamase, fragment, hydrolase |
Biological source | Klebsiella pneumoniae |
Total number of polymer chains | 4 |
Total formula weight | 113907.73 |
Authors | Lund, B.A.,Leiros, H.K.S. (deposition date: 2017-07-11, release date: 2018-01-10, Last modification date: 2023-11-15) |
Primary citation | Akhter, S.,Lund, B.A.,Ismael, A.,Langer, M.,Isaksson, J.,Christopeit, T.,Leiros, H.S.,Bayer, A. A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design. Eur J Med Chem, 145:634-648, 2018 Cited by PubMed: 29348071DOI: 10.1016/j.ejmech.2017.12.085 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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