5QAS

OXA-48 IN COMPLEX WITH COMPOUND 23b

5QAS の概要

• エントリーDOI: 10.2210/pdb5qas/pdb
• Group deposition: A focused fragment library targeting the antibiotic resistance enzyme - oxacillinase-48: synthesis, structural evaluation and inhibitor design (G_1002027)
• 分子名称: Beta-lactamase, 3-[4-(2-acetamidoethyl)phenyl]benzoic acid, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: oxacillinase, inhibitor, complex, oxa, antibiotic resistance, beta-lactamase, fragment, hydrolase
• 由来する生物種: Klebsiella pneumoniae
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 114165.23

構造登録者

Lund, B.A.,Leiros, H.K.S. (登録日: 2017-07-11, 公開日: 2018-01-10, 最終更新日: 2023-11-15)

• 主引用文献: Akhter, S.,Lund, B.A.,Ismael, A.,Langer, M.,Isaksson, J.,Christopeit, T.,Leiros, H.S.,Bayer, A.; A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.; Eur J Med Chem, 145:634-648, 2018; PubMed: 29348071; DOI: 10.1016/j.ejmech.2017.12.085

実験手法

X-RAY DIFFRACTION (1.9 Å)