5P9X
humanized rat catechol O-methyltransferase in complex with N-[1-[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]propan-2-yl]-5-(4-fluorophenyl)-2,3-dihydroxybenzamide
Summary for 5P9X
Entry DOI | 10.2210/pdb5p9x/pdb |
Group deposition | Crystal Structure of COMT complex (G_1002014) |
Descriptor | Catechol O-methyltransferase, MAGNESIUM ION, CHLORIDE ION, ... (7 entities in total) |
Functional Keywords | methyltransferase, neurotransmitter degradation, transferase |
Biological source | Rattus norvegicus (Rat) |
Cellular location | Isoform 2: Cytoplasm. Isoform 1: Cell membrane; Single-pass type II membrane protein; Extracellular side: P22734 |
Total number of polymer chains | 1 |
Total formula weight | 25617.40 |
Authors | Ehler, A.,Lerner, C.,Rudolph, M.G. (deposition date: 2016-10-19, release date: 2017-11-22, Last modification date: 2024-04-03) |
Primary citation | Lerner, C.,Jakob-Roetne, R.,Groebke-Zbinden, K.,Buettelmann, B.,Rudolph, M.G. Crystal Structure of a COMT complex To be published, |
Experimental method | X-RAY DIFFRACTION (1.12 Å) |
Structure validation
Download full validation report