5P9S

humanized rat COMT in complex with 8-hydroxy-6-[3-methyl-5-(4-methylpiperazine-1-carbonyl)thiophen-2-yl]-3H-quinazolin-4-one

5P9S の概要

• エントリーDOI: 10.2210/pdb5p9s/pdb
• Group deposition: Crystal Structure of COMT complex (G_1002014)
• 分子名称: Catechol O-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: methyltransferase, neurotransmitter degradation, transferase
• 由来する生物種: Rattus norvegicus (Rat)
• 細胞内の位置: Isoform 2: Cytoplasm. Isoform 1: Cell membrane; Single-pass type II membrane protein; Extracellular side: P22734
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 25487.50

構造登録者

Ehler, A.,Jakob-Roetne, R.,Rudolph, M.G. (登録日: 2016-10-19, 公開日: 2017-11-22, 最終更新日: 2024-04-03)

• 主引用文献: Lerner, C.,Jakob-Roetne, R.,Groebke-Zbinden, K.,Buettelmann, B.,Rudolph, M.G.; Crystal Structure of a COMT complex; To be published,

実験手法

X-RAY DIFFRACTION (2.3 Å)