5P9O

humanized rat COMT in complex with 7-fluoro-5,6-bis(4-fluorophenyl)-8-hydroxy-3H-quinazolin-4-one

5P9O の概要

• エントリーDOI: 10.2210/pdb5p9o/pdb
• Group deposition: Crystal Structure of COMT complex (G_1002014)
• 分子名称: Catechol O-methyltransferase, 7-fluoranyl-5,6-bis(4-fluorophenyl)-8-oxidanyl-3~{H}-quinazolin-4-one, S-ADENOSYL-L-HOMOCYSTEINE, ... (9 entities in total)
• 機能のキーワード: methyltransferase, neurotransmitter degradation, transferase
• 由来する生物種: Rattus norvegicus (Rat)
• 細胞内の位置: Isoform 2: Cytoplasm. Isoform 1: Cell membrane; Single-pass type II membrane protein; Extracellular side: P22734
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 26265.75

構造登録者

Ehler, A.,Lerner, C.,Rudolph, M.G. (登録日: 2016-10-19, 公開日: 2017-11-22, 最終更新日: 2024-04-03)

• 主引用文献: Lerner, C.,Jakob-Roetne, R.,Groebke-Zbinden, K.,Buettelmann, B.,Rudolph, M.G.; Crystal Structure of a COMT complex; To be published,

実験手法

X-RAY DIFFRACTION (1.1 Å)