5P9M
BTK1 BINDS COVALENTLY TO HY-15771 ONO-4059
Summary for 5P9M
Entry DOI | 10.2210/pdb5p9m/pdb |
Group deposition | Crystal structures of Tyrosine-protein kinase BTK in complex with inhibitors (G_1002011) |
Descriptor | Tyrosine-protein kinase BTK, 6-azanyl-9-[(3~{R})-1-[(~{E})-but-2-enoyl]pyrrolidin-3-yl]-7-(4-phenoxyphenyl)purin-8-one, DIMETHYL SULFOXIDE, ... (4 entities in total) |
Functional Keywords | kinase, kinase-ligand complex, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: Q06187 |
Total number of polymer chains | 1 |
Total formula weight | 32860.70 |
Authors | Gardberg, A.S. (deposition date: 2016-09-20, release date: 2017-05-24, Last modification date: 2021-11-17) |
Primary citation | Bender, A.T.,Gardberg, A.,Pereira, A.,Johnson, T.,Wu, Y.,Grenningloh, R.,Head, J.,Morandi, F.,Haselmayer, P.,Liu-Bujalski, L. Ability of Bruton's Tyrosine Kinase Inhibitors to Sequester Y551 and Prevent Phosphorylation Determines Potency for Inhibition of Fc Receptor but not B-Cell Receptor Signaling. Mol. Pharmacol., 91:208-219, 2017 Cited by PubMed: 28062735DOI: 10.1124/mol.116.107037 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.41 Å) |
Structure validation
Download full validation report