5P9I
BTK1 SOAKED WITH IBRUTINIB-Rev
Summary for 5P9I
| Entry DOI | 10.2210/pdb5p9i/pdb |
| Group deposition | Crystal structures of Tyrosine-protein kinase BTK in complex with inhibitors (G_1002011) |
| Descriptor | Tyrosine-protein kinase BTK, 1-{(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one, DIMETHYL SULFOXIDE, ... (4 entities in total) |
| Functional Keywords | protein kinase, transferase |
| Biological source | Homo sapiens (Human) |
| Cellular location | Cytoplasm: Q06187 |
| Total number of polymer chains | 1 |
| Total formula weight | 32922.83 |
| Authors | Gardberg, A.S. (deposition date: 2016-09-20, release date: 2017-05-24, Last modification date: 2021-11-17) |
| Primary citation | Bender, A.T.,Gardberg, A.,Pereira, A.,Johnson, T.,Wu, Y.,Grenningloh, R.,Head, J.,Morandi, F.,Haselmayer, P.,Liu-Bujalski, L. Ability of Bruton's Tyrosine Kinase Inhibitors to Sequester Y551 and Prevent Phosphorylation Determines Potency for Inhibition of Fc Receptor but not B-Cell Receptor Signaling. Mol. Pharmacol., 91:208-219, 2017 Cited by PubMed: 28062735DOI: 10.1124/mol.116.107037 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.11 Å) |
Structure validation
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