5OU2
M. thermoresistible IMPDH in complex with IMP and Compound 2 (NMR744)
Summary for 5OU2
Entry DOI | 10.2210/pdb5ou2/pdb |
Descriptor | Inosine-5'-monophosphate dehydrogenase,Inosine-5'-monophosphate dehydrogenase, INOSINIC ACID, 4-(4-bromophenyl)-1H-imidazole, ... (4 entities in total) |
Functional Keywords | complex, fragment, impdh, oxidoreductase |
Biological source | Mycobacterium thermoresistibile (strain ATCC 19527 / DSM 44167 / CIP 105390 / JCM 6362 / NCTC 10409 / 316) More |
Total number of polymer chains | 1 |
Total formula weight | 40648.82 |
Authors | Ascher, D.B.,Pacitto, A.,Blundell, T.L. (deposition date: 2017-08-23, release date: 2018-03-28, Last modification date: 2024-05-08) |
Primary citation | Trapero, A.,Pacitto, A.,Singh, V.,Sabbah, M.,Coyne, A.G.,Mizrahi, V.,Blundell, T.L.,Ascher, D.B.,Abell, C. Fragment-Based Approach to Targeting Inosine-5'-monophosphate Dehydrogenase (IMPDH) from Mycobacterium tuberculosis. J. Med. Chem., 61:2806-2822, 2018 Cited by PubMed: 29547284DOI: 10.1021/acs.jmedchem.7b01622 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.45 Å) |
Structure validation
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